APRIL 28, 2020 | Plasma therapy was approved for trial and clinical research proposals were also floated to see whether plasma therapy can be a cure for Coronavirus2 which has made more than 2 lakh fatalities around the world. But the therapy has been declared unproven and unsafe by ICMR, India as on 28th April 2020.
Plasma therapy involves isolation of plasma (blood component) which carries important molecules like antibodies, other proteins, metals etc. This plasma of infected might have two important characteristics, one is presence of specific antibodies (Abs) (for viral proteins or RNA) and second is to have these in sufficient quantities (to elicit antibody generation and virus neutralization).
Earlier it was suggested that the generation of specific Ab takes around 21 days. So finding plasma which might have components required becomes too difficult because patient does not survive beyond 14-17 days in severe CoV2 infection.
Vaccine on other hand contains specific molecules unlike plasma. It either have specific Ab or material that can start production of Abs against the virus.
Finding patients having right plasma is still a subject of investigation and Convalescent plasma therapy can create life-threatening complications in a Covid-19 patient and is still experimental, the ministry of health and family welfare warned. ICMR has put a ban on use of plasma therapy.