The transdermal drug delivery system (TDDS) has proved as one of the most promising method for new drug delivery system. To overcome the disadvantages associated with conventional dosage form, this area is an exciting and challenging field of pharmaceutical R & D. With transdermal drug delivery system one can deliver drugs through the skin to systemic circulation at a predetermined rate and maintain clinically effective concentration over prolonged period of time, taking advantage of passive transport method, diffusion. By the help of this advanced modern technology, through effective formulation, development and evaluation a large number of drugs can be delivered, eliminating the troubles of frequent dosing and plasma level peaks. Over the last two decades many such patches are approved worldwide. As the drug administered by TDDS bypass the gastrointestinal tract (GI) thus avoid metabolism by liver, there is lesser chances of side effects like GI irritation and liver dysfunction.
Key Words : Transdermal Drug Delivery System, Skin Permeability, Polymeric matrix , Patch
By Dipanwita Bhattacharjee, Pritha Roy and Barun K. Bhattacharyya*Biotechnology – R&D, East India Pharmaceutical Works Ltd
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